Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove.
This report describes a breakthrough in a project to design minor groove binders to recognize any sequence of DNA. A key goal is to invent synthetic chemistry for comp...
Two-Dimensional Metalloporphyrinic Framework Nanosheet-Based Dual-Mechanism-Driven Ratiometric Electrochemiluminescent Biosensing of Protein Kinase Activity.
A dual-mechanism-driven ratiometric electrochemiluminescent (ECL) biosensor was developed for the ultrasensitive detection of protein kinase activity, which was based ...
Cancer Cell Detection on the Surface of Top-Gated Monolayer Graphene via Raman Spectroscopy.
A label-free biosensor is described based on the Raman spectroscopic signatures of monolayer graphene, which are modified in the compartment of cancer cells because of...
Biochar-Supported Cu
Ractopamine as an important β-agonist is frequently found in pork to enhance food quality, which is harmful to human health. Thus, it is extremely important to develop...
Surface Biochemical Modification of Poly(dimethylsiloxane) for Specific Immune Cytokine Response.
Recent evidence suggests that proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), play a pivotal role in the development of inflammatory-related pathol...
High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition.
Optical biosensors are sensitive devices used in bioanalytics detection. Analysis of blood constituents is very important for the detection of major diseases and also ...
Cu(I)-Catalyzed Click Reaction-Triggered 3D DNA Walker for Constructing an "OFF-ON" Fluorescent Biosensor for Cu
Herein, a highly selective and sensitive "OFF-ON" fluorescent biosensor was designed for intracellular Cu2+ detection. Compared to the fluorescent Cu2+ biosensors repo...
Poly-l-lysine-Functionalized Green-Light-Emitting Carbon Dots as a Fluorescence Turn-on Sensor for Ultrasensitive Detection of Endotoxin.
Herein, we report a facile, ultrasensitive, and selective fluorescence turn-on sensing strategy based on green-light-emitting functional nanodots for the detection of ...
3D Flower-like NiCo Layered Double Hydroxides: An Efficient Electrocatalyst for Non-Enzymatic Electrochemical Biosensing of Hydrogen Peroxide in Live Cells and Glucose in Biofluids.
Herein, a hierarchical structure of flower-like NiCo layered double hydroxides (NiCo LDH) microspheres composed of three-dimensional (3D) ultrathin nanosheets was succ...
SERS Based Lateral Flow Immunoassay for Point-of-Care Detection of SARS-CoV-2 in Clinical Samples.
The current scenario, an ongoing pandemic of COVID-19, places a dreadful burden on the healthcare system worldwide. Subsequently, there is a need for a rapid, user-fri...
Functional Comparison of Bioactive Cellulose Materials Incorporating Engineered Binding Proteins.
Whatman No. 1 chromatography paper is widely used as a substrate for cellulose-based immunoassays. The immobilized proteins are used to capture target biomarkers for d...
The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors.
Here, we propose and study several types of quartz surface coatings designed for the high-performance sorption of biomolecules and their subsequent detection by a phot...
An Electrochemical Immunosensor Based on SPA and rGO-PEI-Ag-Nf for the Detection of Arsanilic Acid.
A sensitive electrochemical immunosensor was prepared for rapid detection of ASA based on arsanilic acid (ASA) monoclonal antibody with high affinity. In the preparati...
Quorum Sensing Bacteria in the Phycosphere of HAB Microalgae and Their Ecological Functions Related to Cross-Kingdom Interactions.
It has been proven that the relationship between microalgae and bacteria affects the dynamic process of harmful algal blooms (HABs). Microalgae-associated microorganis...
DNAzyme-Amplified Electrochemical Biosensor Coupled with pH Meter for Ca
For more than 50% of multiparous cows, it is difficult to adapt to the sudden increase in calcium demand for milk production, which is highly likely to cause hypocalce...
Sandwich Integration Technique for the Pressure Sensor Detection of Occlusal Force In Vitro.
Bite force measurement is an important parameter when checking the function and integrity of the masticatory system, whereas it is currently very difficult to measure ...
Advances in Design Strategies of Multiplex Electrochemical Aptasensors.
In recent years, the need for simple, fast, and economical detection of food and environmental contaminants, and the necessity to monitor biomarkers of different disea...
Fabrication of AuNPs/MWCNTS/Chitosan Nanocomposite for the Electrochemical Aptasensing of Cadmium in Water.
Cadmium (Cd2+) is one of the most toxic heavy metals causing serious health problems; thus, designing accurate analytical methods for monitoring such pollutants is hig...
A Sensitive Capacitive Biosensor for Protein a Detection Using Human IgG Immobilized on an Electrode Using Layer-by-Layer Applied Gold Nanoparticles.
A capacitive biosensor for the detection of protein A was developed. Gold electrodes were fabricated by thermal evaporation and patterned by photoresist photolithograp...