Integrating Highly Efficient Recognition and Signal Transition of g-C
Herein, a novel electrogenerated chemiluminescence (ECL) method for highly sensitive kinase activity and inhibitors screening was developed based on graphitic carbon n...
Detection of Cardiovascular CRP Protein Biomarker Using a Novel Nanofibrous Substrate.
It is known that different diseases have characteristic biomarkers that are secreted very early on, even before the symptoms have developed. Before any kind of therape...
A Capillary-Perfused, Nanocalorimeter Platform for Thermometric Enzyme-Linked Immunosorbent Assay with Femtomole Sensitivity.
Enzyme-catalyzed chemical reactions produce heat. We developed an enclosed, capillary-perfused nanocalorimeter platform for thermometric enzyme-linked immunosorbent as...
Single Iron Site Nanozyme for Ultrasensitive Glucose Detection.
Nanomaterials with enzyme-mimicking characteristics have engaged great awareness in various fields owing to their comparative low cost, high stability, and large-scale...
SPR enhanced DNA biosensor for sensitive detection of donkey meat adulteration.
Herein, a surface plasmon resonance (SPR) enhanced DNA biosensor has been developed for real-time detection of donkey meat marker using biotinylated reporter and strep...
Phase-transfer-assisted synthesis of cysteine-Ag nanoparticles/graphene oxide nanocomposite and its enhanced performance in antibiosis and biosensing.
We report a facile, rapid, phase-transfer-assisted process to prepare Ag nanoparticles (AgNP) loaded graphene oxide (GO) nanocomposite, by using cysteine as a highly-e...
Differential endothelial signaling responses elicited by chemogenetic H
Hydrogen peroxide (H2O2) modulates critical phosphorylation pathways in vascular endothelial cells, many of which affect endothelial nitric oxide synthase (eNOS) signa...
Epidermal Patch with Glucose Biosensor: pH and Temperature Correction toward More Accurate Sweat Analysis during Sport Practice.
We present an epidermal patch for glucose analysis in sweat incorporating for the first time pH and temperature correction according to local dynamic fluctuations in s...
An overview and future prospects on aptamers for food safety.
INTRODUCTION: Many bacteria are responsible for infections in humans and plants, being found in vegetables, water, and medical devices. Most bacterial detection method...
Scattering Fourier Transform Biosensor: Binary Mixture Consisting of Magnetic Ni Nanorings and Plasmonic Au Nanorods.
We report a biosensing platform based on a binary mixture comprised of Au nanorods (plasmonic nanoparticles, Au NRs) and magnetically responsive Pt@Ni nanorings (magne...
Glial glutamate transporter GLT-1 determines susceptibility to spreading depression in the mouse cerebral cortex.
Cortical spreading depression (CSD) is a pathological neural excitation that underlies migraine pathophysiology. Since glutamate receptor antagonists impair CSD propag...
A practical method for fabricating superparamagnetic films and the mechanism involved.
Due to the widespread applications of biosensors, such as in magnetic resonance imaging, cancer detection and drug delivery, the use of superparamagnetic materials for...
Bioluminescence-Triggered Photoswitchable Bacterial Adhesions Enable Higher Sensitivity and Dual-Readout Bacterial Biosensors for Mercury.
We present a new concept for whole-cell biosensors that couples the response to Hg2+ with bioluminescence and bacterial aggregation. This allows us to use the bacteria...
Electrochemical impedimetric biosensors for food safety.
Electrochemical impedimetric biosensors (EIBs) have a simple structure and can be used to rapidly and sensitively detect and measure hazards in food. EIBs detect and m...
Laccase-Based Biosensor Encapsulated in a Galactomannan-Chitosan Composite for the Evaluation of Phenolic Compounds.
Galactomannan, a neutral polysaccharide, was extracted from carob seeds and characterized. It was used for the first time for the fabrication of a laccase-based biosen...
Functional Heterogeneity of Protein Kinase A Activation in Multipotent Stromal Cells.
Multipotent stromal cells (MSC) demonstrate remarkable functional heterogeneity; however, its molecular mechanisms remain largely obscure. In this study, we explored M...
Three-Dimensional Microtumors for Probing Heterogeneity of Invasive Bladder Cancer.
Bladder cancer is an increasingly common malignancy, and muscle invasive bladder cancer is associated with particularly high rates of morbidity and mortality. The morp...
Label-Free Bimetallic In Situ-Grown 3D Nickel-Foam-Supported NH
In this study, a simple and competent metal-organic framework (MOF)-based nickel foam (NF)-supported three-dimensional (3D) immunosensor (Ab-NH2-MIL-88B(Fe2Co)-MOF/NF)...
An electrochemical biosensor exploiting binding-induced changes in electron transfer of electrode-attached DNA origami to detect hundred nanometer-scale targets.
The specific detection in clinical samples of analytes with dimensions in the tens to hundreds of nanometers, such as viruses and large proteins, would improve disease...
Real-time monitoring of the in vivo redox state transition using the ratiometric redox state sensor protein FROG/B.
The intracellular redox state is one of the key factors regulating various physiological phenomena in the cell. Monitoring this state is therefore important for unders...