Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes.
Early detection and effective treatments are two of the greatest challenges in the fight against cancer. Cancer-derived exosomes are attractive biomarkers for the earl...
MyoRobot 2.0: An advanced biomechatronics platform for automated, environmentally controlled skeletal muscle single fiber biomechanics assessment employing inbuilt real-time optical imaging.
We present an enhanced version of our previously engineered MyoRobot system for reliable, versatile and automated investigations of skeletal muscle or linear polymer m...
Rapid antibiotic susceptibility testing by resazurin using thin film platinum as a bio-electrode.
Traditional antibiotic susceptibility testing methods take several days to confirm and start disease treatment. The lack of new antibiotics or drugs warrants a need fo...
Rapid synthesis of Au/Ag bimetallic nanoclusters with highly biochemical stability and its applications for temperature and ratiometric pH sensing.
Herein, we developed a simple and rapid strategy to synthesize gold/silver bimetallic nanoclusters (Au/Ag NCs) with highly biochemical stability by a one-pot route. Th...
Novel coreactant modifier-based amplified electrochemiluminescence sensing method for point-of-care diagnostics of galactose.
Herein, an innovative coreactant modifier-based amplified ECL sensing method was developed to provide a convenient and effective amplified ECL emission. Firstly, nitro...
A novel disposable self-adhesive inked paper device for electrochemical sensing of dopamine and serotonin neurotransmitters and biosensing of glucose.
In this work, we detail the progress of a novel electrochemical disposable device, which has a relatively low cost and easy production, with a novel conductive ink, th...
A label-free PFP-based photoelectrochemical biosensor for highly sensitive detection of PARP-1 activity.
Poly(ADP-ribose) polymerase-1 (PARP-1), as an original tumor marker, has aroused wide attention in recent years. However, only a few researches have been done for PARP...
Fabrication of a κ-carrageenan-based electroactive cytochrome c multilayer thin film by an electrostatic layer-by-layer assembly.
The aim of this study was to demonstrate the usability of κ-carrageenan in the accumulation of a layer by layer protein film on a gold electrode. It is known that in t...
Ultrasound-assisted synthesis of tungsten trioxide entrapped with graphene nanosheets for developing nanomolar electrochemical (hormone) sensor and enhanced sensitivity of the catalytic performance.
Herein, we have reported a simple sonochemical synthesis of multi-layer graphene covered tungsten trioxide nanoballs (WO3 NBs) and the nanocomposite was characterized ...
Quantitative assessment of disease markers using the naked eye: point-of-care testing with gas generation-based biosensor immunochromatographic strips.
BACKGROUND: Immunochromatographic strips (ICSs) are a practical tool commonly used in point-of-care testing (POCT) applications. However, ICSs that are currently avail...
Low-cost and user-friendly biosensor to test the integrity of mRNA molecules suitable for field applications.
The use of mRNA in biotechnology has expanded with novel applications such as vaccines and therapeutic mRNA delivery recently demonstrated. For mRNA to be used in pati...
Precise, direct, and rapid detection of Shigella Spa gene by a novel unmodified AuNPs-based optical genosensing system.
Early detection of infectious bacteria is a necessity for combating infectious diseases. Due to low infectious dose of Shigella, rapid and sensitive detection is neede...
Efficient development and expression of scFv recombinant proteins against PD-L1 surface domain and potency in cancer therapy.
PD-L1 is a 40 kDa trans-membrane protein of B7 family and an important T cell regulator. Binding of PD-L1 and PD-1 inhibits proliferation and activation of T cell resu...
Detection of unamplified target genes via CRISPR-Cas9 immobilized on a graphene field-effect transistor.
Most methods for the detection of nucleic acids require many reagents and expensive and bulky instrumentation. Here, we report the development and testing of a graphen...
Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity.
Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes...
FÖrster resonance energy transfer (FRET)-based biosensors for biological applications.
FÖrster resonance energy transfer (FRET)-based biosensors have achieved great success for biological applications. However, what is not extensively appreciated is the ...
Direct PCR-free electrochemical biosensing of plant-food derived nucleic acids in genomic DNA extracts. Application to the determination of the key allergen Sola l 7 in tomato seeds.
A novel and disposable electrochemical biosensor for PCR-free and selective detection of Sola l 7, a non-specific lipid transfer protein (nsLTP) found in tomato seeds ...
Enhanced 3D paper-based devices with a personal glucose meter for highly sensitive and portable biosensing of silver ion.
A variety of routine methods are available for the detection of silver (I) (Ag+) ions, but most of them rely on expensive, sophisticated and desktop instruments. Herei...
Black phosphorus based fiber optic biosensor for ultrasensitive cancer diagnosis.
We propose the first black phosphorus (BP) - fiber optic biosensor for ultrasensitive diagnosis of human neuron-specific enolase (NSE) cancer biomarkers. A novel optic...
DNA three-way junction-actuated strand displacement for miRNA detection using a fluorescence light-up Ag nanocluster probe.
A rapid and label-free fluorescence biosensing strategy for highly sensitive detection of microRNA-122 (miR-122) has been developed by the combination of DNA three-way...