Interplay between compartmentalized NAD
Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for redox enzymes, but also moonlights as a substrate for signaling enzymes. When used as a substrate...
In vitro selection of DNA aptamers and their integration in a competitive voltammetric biosensor for azlocillin determination in waste water.
The uncontrolled usage of veterinary antibiotics has led to their widespread pollution in waterways and milk products. Potential impact of antibiotic residues on the e...
A new bivalent fluorescent fusion protein for differential Cu(II) and Zn(II) ion detection in aqueous solution.
Simple and easy to engineer metal-sensing molecules that are capable of differentiating metal ions and producing metal-specific signals are highly desirable. Metal ion...
Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis.
Since the norovirus is the main cause of acute gastroenteritis all over the world, its fast detection is crucial in medical diagnostics. In this work, a rapid, sensiti...
KinCon: Cell-based recording of full-length kinase conformations.
The spectrum of kinase alterations displays distinct functional characteristics and requires kinase mutation-oriented strategies for therapeutic interference. Besides ...
Electrochemiluminescence immunoassay for the prostate-specific antigen by using a CdS/chitosan/g-C
An electrochemiluminescence (ECL) biosensor was fabricated for the evaluation of prostate specific antigen (PSA). The sensor was developed by successively modifying gl...
Neuronal programming by microbiota regulates intestinal physiology.
Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host defence...
CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain.
Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dyna...
An Electrochemical Biosensor Designed by Using Zr-Based Metal-Organic Frameworks for the Detection of Glioblastoma-Derived Exosomes with Practical Application.
Glioblastoma (GBM) is one of the most fatal tumors in the brain, and its early diagnosis remains technically challenging due to the complex repertoires of oncogenic al...
Recent Advances in the Development of Biosensors for Malaria Diagnosis.
The impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate a...
Development of High-Performance Whole Cell Biosensors Aided by Statistical Modeling.
Whole cell biosensors are genetic systems that link the presence of a chemical, or other stimulus, to a user-defined gene expression output for applications in sensing...
Phosphatidic acid produced by phospholipase D is required for hyphal cell-cell fusion and fungal-plant symbiosis.
Although lipid signaling has been shown to serve crucial roles in mammals and plants, little is known about this process in filamentous fungi. Here we analyze the cont...
Simulated revelation of the adsorption behaviours of acetylcholinesterase on charged self-assembled monolayers.
An acetylcholinesterase (AChE)-based electrochemical biosensor, as a promising alternative to detect organophosphates (OPs) and carbamate pesticides, has gained consid...
A Visual FRET Immunofluorescent Biosensor for Ratiometric Parathyroid Hormone (1-84) Antigen Point-of-Care Detection.
Excessive secretion of PTH leads to disturbance of calcium and phosphorus metabolism in the body, which promotes bone, kidney, digestive system and nervous system dise...
Biomembrane-based organic electronic devices for ligand-receptor binding studies.
We present a simple, rapid method for forming supported lipid bilayers on organic electronic devices composed of conducting polymer electrodes using a solvent-assisted...
A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework.
The kinetics/dynamics of signaling are of increasing value for G-protein-coupled receptor therapeutic development, including spatiotemporal signaling and the kinetic c...
Understanding mercury methylation in the changing environment: Recent advances in assessing microbial methylators and mercury bioavailability.
Methylmercury (MeHg) is a neurotoxin, mainly derived from microbial mercury methylation in natural aquatic environments, and poses threats to human health. Polar regio...
Critical parameters in surface plasmon resonance biosensor development: The interaction between estrogen receptor and estrogen response element as model.
Estrogenic compounds are contaminants that may be active at low concentrations and are a major concern for environmental quality. They interact with organisms via Estr...
High-performance biosensing based on autonomous enzyme-free DNA circuits.
Nucleic acids are considered not only extraordinary carriers of genetic information but also are perceived as the perfect elemental materials of molecular recognition ...
A visual electrochemiluminescence biosensor based on CuInZnS quantum dots for superoxide dismutase detection.
Superoxide dismutase (SOD), also known as liver protein, is a substance widely distributed in various biological cells. It has the function of catalyzing the dispropor...