Identification of a new anti-LPS agent, geniposide, from Gardenia jasminoides Ellis, and its ability of direct binding and neutralization of lipopolysaccharide in vitro and in vivo.
脂多糖(LPS/内毒素)是脓毒症的关键病原体识别分子。目前重症脓毒症治疗策略之一是中和LPS,临床试验显示许多传统中药具有抗脓毒症功能。为阐明可中和LPS的传统中药生物活性成分,本研究采用亲和生物传感器技术检测60种中药的脂质A结合能力。栀子(Gardenia jasminoides Ellis)水提物被进一步研究,随后分离得到单体...