An ultrasensitive electrochemical biosensor for detection of DNA species related to oral cancer based on nuclease-assisted target recycling and amplification of DNAzyme.
本文报道了一种简单、无标记、超高灵敏且高选择性的电化学生物传感器,用于唾液中口腔癌相关DNA物种(ORAOV1)检测。该传感器以金电极为基底,3′端巯基修饰的信号探针(Sp)通过S–Au键固定,并用2-巯基乙醇(MCH)封闭形成混合单分子层。Sp包含目标识别序列和富含G序列,且识别序列内嵌N.BstNB I切口内切酶识别位点。当完全...