A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate.
由镧系(III)离子与1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA4-)衍生物组成的响应性对比剂(RCA)在磁共振分子成像中具有重要潜力。化学交换饱和转移(CEST)通过检测体水与配体可交换位点或内球结合水之间的质子交换产生对比,其中顺磁镧系离子使结合水信号发生显著化学位移。生物传感器成像冗余位移偏差(BIR...