Neuroprotective effects of angiotensin II type 1 receptor (AT1-R) blocker via modulating AT1-R signaling and decreased extracellular glutamate levels.

目的：研究血管紧张素II 1型受体（AT1-R）阻断剂坎地沙坦对大鼠视网膜缺血再灌注损伤的神经保护机制。方法：通过升高眼压诱导大鼠视网膜缺血，使用微透析生物传感器和氧敏感微电极在缺血及再灌注期间监测玻璃体谷氨酸释放和氧分压（PO2）；ELISA检测AT1-R表达变化；实时PCR检测视网膜p47phox和p67phox mRNA；二氢...