Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts.

目的：转移性前列腺癌中HER2表达与雄激素非依赖性相关，放射性核素分子影像可识别HER2表达并筛选靶向治疗患者。Affibody分子是约7 kDa的小型靶向蛋白，适合放射性影像。本研究旨在开发前列腺癌HER2显像的最优Affibody探针。方法：将抗HER2 ZHER2:342 Affibody变体ZHER2:S1在N端分别偶联DO...