Ultrasensitive Biosensor for Detection of Mercury(II) Ions Based on DNA-Cu Nanoclusters and Exonuclease III-assisted Signal Amplification.

本文描述了一种基于双链DNA模板铜纳米簇（CuNCs）和外切酶III（Exo III）诱导靶信号循环放大的无标记汞(II)离子检测方法。所合成的DNA-Cu纳米簇与Exo III环放大技术结合，用于超高灵敏度检测汞(II)离子，检测信号表现为荧光强度显著降低。在最优实验条件下，Hg2+浓度在0.04–8 nM范围内与荧光强度呈明显线...