Nano-bio-chips for high performance multiplexed protein detection: determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels.
本研究将半导体纳米颗粒量子点(QDs)整合到模块化微流控生物传感器中,用于癌胚抗原(CEA)、癌抗原125(CA125)和Her-2/Neu(C-erbB-2)三种重要癌症标志物的多重定量。该纳米生物芯片采用荧光转导信号,以QD标记的检测抗体与微流控系统中琼脂糖微孔微球阵列支持的抗原捕获相结合,完成夹心免疫分析,并已在血清和全唾液标...