Spatially-extended 3D magnetic DNA nanodevice-based split-type photoelectrochemical strategy for sensitive and reliable miRNA detection in cancer cells.

针对miRNA高灵敏可靠光电化学检测受共存干扰影响准确性等挑战，本文开发基于空间扩展三维磁性DNA纳米器件和高阶DNA放大器的分体式“关型”光电化学生物传感器，用于癌细胞中miRNA灵敏检测。锁式探针与miR-21两端互补，触发滚环扩增产生RCA-DNA，作为骨架经生物素化P1、P2、P3周期性结合折叠自组装成高阶DNA支架，并通过...