2 条结果 关键词:细胞周期 ×

A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

Developmental cell 2018 Ford MJ, Yeyati PL, Mali GR, Keighren MA 等 15 人

纤毛与细胞周期通过共享的中心粒/基体机制紧密偶联。中心粒在纤毛基体中成核纤毛轴丝,并在中心体处隔离周中心粒基质以组织有丝分裂纺锤体;纤毛可响应生长信号,触发纤毛回缩和细胞周期再进入。本文报道一种荧光纤毛/细胞周期生物传感器,可在细胞和诱导型小鼠中同时标记细胞周期阶段与纤毛组装/解聚动力学,实现活体成像。该三顺反子报告系统包含 ARL...

Involvement of organic acids and amino acids in ameliorating Ni(II) toxicity induced cell cycle dysregulation in Caulobacter crescentus: a metabolomics analysis.

Applied microbiology and biotechnology 2018 Jain A, Chen WN

镍(Ni(II))毒性可被多种细菌应对,但细菌对镍胁迫的响应机制仍不清楚。本研究考察 Ni(II) 毒性对 α-变形菌弯曲柄杆菌(Caulobacter crescentus)细胞增殖的影响,并揭示其在镍胁迫下存活的机制。结果显示,不同浓度 Ni(II) 显著影响弯曲柄杆菌生长:0.003 mM 仅轻微影响生长,0.008 mM 使...