Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains.
人肾小管上皮细胞被认为是志贺毒素(Stx)介导的溶血性尿毒症综合征(HUS)发病机制中的靶细胞,HUS由产Stx肠出血性大肠杆菌(EHEC)引起。对原代人肾近端小管上皮细胞(pHRPTEpiCs)中Stx结合糖鞘脂(GSL)的分析显示,主要受体为三己糖神经酰胺(Gb3Cer)和四己糖神经酰胺(Gb4Cer),优势脂形式为Cer(d1...