Rapid and sensitive detection of nodularin-R in water by a label-free BLI aptasensor.

淡水水体中节球藻素R（NOD-R）污染是重要的环境与公共健康问题。现有小鼠生物试验、HPLC、LC-MS、毛细管电泳及ELISA等方法存在伦理争议、耗时、昂贵或交叉反应等不足。本文以SELEX筛选的DNA适配体为特异性识别元件，构建了无标记生物层干涉（BLI）适配体传感器用于NOD-R检测。该传感器检测范围为40–600 nM，线性...