Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.

作者近期报道金黄色葡萄球菌免疫逃逸分子Sbi与补体C3的相互作用，主要由C3d(g)结合Sbi第IV结构域（Sbi-IV）介导。基于这些研究，作者通过定点突变分析C3d与Sbi-IV的结合界面，并重新审视C3d上补体受体2（CR2）结合位点的争议。此前发现Sbi III-IV片段结合C3dg会抑制C3dg与CR2结合；而C3d与Ef...