Novel application of surface plasmon resonance biosensor chips for measurement of advanced glycation end products in serum of Zucker diabetic fatty rats.

晚期糖基化终末产物（AGEs）与糖尿病并发症密切相关。为测定Zucker糖尿病肥胖大鼠（ZDF）和Zucker瘦大鼠（ZL）血清中AGEs，尤其是Nε-(羧甲基)赖氨酸（CML）的水平，作者采用蛋白芯片与表面等离子共振成像（SPRI）新方法。20周龄雄性ZDF和ZL大鼠血清样品中，抗AGEs或抗CML抗体被固定于经半胱氨酸标记蛋白G...