3 条结果 关键词:G-四链体 ×

A fluorescent aptasensor for potassium ion detection-based triple-helix molecular switch.

Analytical biochemistry 2014 Verdian-Doghaei A, Housaindokht MR, Abnous Kh

本文报道了一种基于三螺旋分子开关和四链体形成适配体的钾离子荧光适配体传感器。该传感器以适配体作为分子识别元件,适配体两侧连接两个臂片段,并与一条双标记寡核苷酸信号转导探针(STP)互补,STP序列与臂片段互补。无K+时,适配体与STP形成三螺旋结构;存在K+时,适配体从STP上解离,并伴随荧光信号降低。荧光强度猝灭率与K+浓度在0....

Ultrasensitive fluorescence detection of nucleic acids using exonuclease III-induced cascade two-stage isothermal amplification-mediated zinc (II)-protoporphyrin IX/G-quadruplex supramolecular fluorescent nanotags.

Biosensors & bioelectronics 2014 Xue Q, Lv Y, Zhang Y, Xu S 等 11 人

本研究建立了一种用于超低浓度DNA检测的级联荧光传感系统,将磁性纳米颗粒(MNPs)与外切酶III(Exo III)诱导的级联两阶段等温扩增相结合。设计并固定于MNPs上的捕获发夹探针(CHP)同时包含目标结合序列和信号转导序列。当目标核酸存在时,CHP打开并被Exo III逐步切除,释放目标DNA用于后续杂交与切割,同时暴露CHP...

Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection.

Analytica chimica acta 2014 Chen J, Lin J, Zhang X, Cai S 等 8 人

乳腺癌的非侵入性早期诊断是提高生存率和保留乳房机会的关键。本文开发了一种基于核酸外切酶III辅助靶标循环和硫黄素T诱导G-四链体形成的无标记荧光生物传感器,用于唾液中c-erbB-2短DNA片段的检测。该体系由G/P双链DNA探针、ThT和Exo III组成。靶标T1与探针杂交后形成平末端,Exo III逐步消化探针并释放T1和富含...