FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specific.
NADPH-细胞色素P450还原酶(CPR)通过FAD和FMN将NADPH提供的两个还原当量以单电子转移方式传递给微粒体P450单加氧酶。酵母CPR(yCPR)晶体结构在FMN结合域与连接域界面处发现一个表面暴露的FMN结合位点(FMN2),此外还有大鼠CPR中观察到的埋藏位点。该发现为CPR分子内(FAD与FMN之间)和分子间(F...