Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid.

转化生长因子β激活激酶1（TAK1）在细胞死亡、分化和炎症中发挥关键作用。本研究在皮下植入Lewis肺癌3LL细胞并注射多聚肌苷酸:多聚胞苷酸（PolyI:C）的同基因C57BL/6小鼠中，活体成像TAK1的激活。作者首先开发并表征了基于Förster共振能量转移（FRET）的TAK1活性生物传感器Eevee-TAK1。该传感器对放...