Discovery of TAS2R14 Agonists from Platycodon grandiflorum Using Virtual Screening and Affinity Screening Based on a Novel TAS2R14-Functionalized HEMT Sensor Combined with UPLC-MS Analysis.

TAS2R14是哮喘治疗的重要潜在靶点，发现其激动剂对哮喘治疗具有重要价值。本研究建立了一种结合虚拟筛选、基于新型TAS2R14功能化高电子迁移率晶体管（HEMT）生物传感器的亲和筛选以及UPLC-MS分析的策略，用于从桔梗（Platycodon grandiflorum）中筛选TAS2R14激动剂。基于配体的虚拟筛选得到16个最佳...