Collagen I and III and their decorin modified surfaces studied by atomic force microscopy and the elucidation of their affinity toward positive apolipoprotein B-100 residue by quartz crystal microbalance.
胶原蛋白是细胞外基质的主要成分,也是人体中最丰富的蛋白质,参与动脉粥样硬化发生。本研究将 I 型和 III 型胶原固定于熔融石英毛细管内壁,并用原子力显微镜(AFM)观察其形貌、尺寸和结构;同时以云母表面作为对照。结果表明,胶原的吸附模式不仅随胶原类型变化,基底材料也显著影响纤维形成过程。Decorin 可促进低密度脂蛋白(LDL)...