Lactate is an important monomer for the synthesis of poly-lactate (PLA), which is a substitute for the petrochemical plastics. To achieve the goal of high lactate tite...
BACKGROUND: Sorafenib, a multi-kinase inhibitor, is used as a standard therapy for advanced hepatocellular carcinoma (HCC). However, complete remission has not been ac...
Triplication of the SNCA gene, encoding the protein alpha-Synuclein (αSyn), is a rare cause of aggressive and early-onset parkinsonism. Herein, we generated iPSCs from...
Muscular dystrophies (MDs) are a heterogeneous group of myopathies characterized by progressive muscle weakness leading to death from heart or respiratory failure. MDs...
BACKGROUND: Brucellosis is a zoonotic disease caused by Brucella spp., affecting various animals and humans, leading to significant economic and public health impacts....
Heterotrimeric G protein subunits Gαq and Gα11 are inhibited by two cyclic depsipeptides, FR900359 (FR) and YM-254890 (YM), both of which are being used widely to impl...
TSC1 or TSC2 mutations cause Tuberous Sclerosis Complex (TSC), and lead to mechanistic target of rapamycin (mTOR) hyperactivation evidenced by hyperphosphorylation of ...
Bongkrekic acid (BKA), a highly lethal toxin, has been implicated in frequent poisoning incidents in recent years, posing a serious threat to global food safety and cr...
Toll-like receptors (TLRs) are primary pattern recognition receptors (PRRs), which recognize conserved microbial components. They play important roles in innate immuni...
Peroxiporins are distinct aquaporins (AQP) which, beside water, also facilitate the bidirectional transport of hydrogen peroxide (H2O2) across cellular membranes. H2O2...
The diagnostic process for psychiatric conditions is guided by the Diagnostic and Statistical Manual of Mental Disorders (DSM) in North America. Revisions of the DSM o...
DRAM1 is an infection inducible autophagy modulator, previously shown to promote autophagic and lysosomal defense responses against the intracellular pathogen Mycobact...
Mitochondria are the primary sites for aerobic respiration and play a vital role in maintaining physiologic function at the cellular and organismal levels. Physiologic...
BACKGROUND: Bacillus subtilis is one of the workhorses in industrial biotechnology and well known for its secretion potential. Efficient secretion of recombinant prote...
BACKGROUND: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular m...
Myocardial ischemia/reperfusion (I/R) injury is exacerbated in diabetic individuals and animal models. We tested whether autophagy is an important cellular determinant...
根据论文标题，该文拟报道一种面向神经元生物电子接口的集成生物传感器芯片及微电子系统。其核心思想可能是将生物传感元件与微电子电路集成在同一芯片上，用于记录、监测或刺激神经元的电生理活动，从而建立生物组织与电子器件之间的接口。由于提供的文本仅包含标题、作者、出版信息和撤回声明，未包含摘要、引言、实验方法、器件结构、材料组成、检测对象、信...
本文报道了利用荧光光漂白产生的自由基物种，将水溶性生物分子位点特异性耦合到含富电子位点表面的光引导表面工程策略，并用于生物传感与组织工程。作者首先比较了疏水吸附与光漂白法将 FITC 标记抗 M13K07 噬菌体单克隆抗体固定到差分电容生物传感器的 SiO2 层和聚酯纤维阵列上。结果显示，两种表面上的抗体固定量和功能均优于传统疏水固...
本研究将环境菌地衣芽孢杆菌（Bacillus licheniformis）51.5 分别用携带昆虫荧光素酶基因 lucFF 的穿梭质粒 pCSS810 和携带绿色荧光蛋白基因 gfp 的穿梭质粒 pGFPratiometric 进行电转化，获得生物发光和绿色荧光重组株。随后用不同抗菌剂处理细胞，并测量其生物发光与荧光。结果显示，携带...
本文报道了从嗜热菌 Thermus thermophilus 中克隆、表达并固定化一种新型重组谷氨酸脱氢酶（GDH）。T. thermophilus 基因组中含有两个编码推定 GDH 的基因，其中 TTC1211 基因被克隆并在大肠杆菌中过表达。纯化后的酶为三聚体，能够以 NAD+ 或 NADP+ 为辅因子催化 L-谷氨酸氧化生成 ...