A whole-cell biosensor for the detection of gold.
Geochemical exploration for gold (Au) is becoming increasingly important to the mining industry. Current processes for Au analyses require sampling materials to be tak...
Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform.
We developed a new building block for a protein- and cell-repellant self-assembled monolayer (SAM) from 2-methacryloyloxyethyl phosphorylcholine (MPC) via a simple Mic...
A suspension-cell biosensor for real-time determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces.
A novel lectin-based suspension-cell biosensor for label-free determination of binding kinetics of protein-carbohydrate interactions on cancer cell surfaces using QCM ...
A resol-assisted co-assembly approach to crystalline mesoporous niobia spheres for electrochemical biosensing.
Templated pores: A resol-assisted solvent-evaporation-induced self-assembly (RA-EISA) gives unique ordered mesoporous niobia spheres by using the amphiphilic diblock c...
A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1.
Human arylamine N-acetyltransferase 1 (hNAT1) has become an attractive potential biomarker for estrogen-receptor-positive breast cancers. We describe here the mechanis...
Study on different molecular weights of chitosan as an immobilization matrix for a glucose biosensor.
Two chitosan samples (medium molecular weight (MMCHI) and low molecular weight (LMCHI)) were investigated as an enzyme immobilization matrix for the fabrication of a g...
Ultrasmall metal nanoclusters for bio-related applications.
The study of ultrasmall metal nanoclusters (NCs, ranging from subnanometer to ca 2 nm) is evidently a quickly evolving field in current nanoscience and nanotechnology ...
Integrated interferometric approach to solve microring resonance splitting in biosensor applications.
Silicon-on-insulator microring resonators have proven to be an excellent platform for label-free nanophotonic biosensors. The high index contrast of silicon-on-insulat...
Signal-to-noise ratio enhancement of silicon nanowires biosensor with rolling circle amplification.
Herein, we describe a novel approach for rapid, label-free and specific DNA detection by applying rolling circle amplification (RCA) based on silicon nanowire field-ef...
GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.
A number of G protein-coupled receptors (GPCRs) localize to primary cilia but the functional significance of cilia to GPCR signaling remains incompletely understood. W...
Monitoring of PQQ-dependent glucose dehydrogenase substrate specificity for its potential use in biocatalysis and bioanalysis.
Substrate specificity of 2,7,9-tricarboxypyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase was investigated in biosensor arrangement for understanding the...
Development of a biosensor-based immunogenicity assay capable of blocking soluble drug target interference.
As with other protein therapeutics, trebananib (AMG 386), an investigational peptide Fc-fusion protein ("peptibody") that inhibits angiogenesis by neutralizing the int...
Modulation of enzyme catalytic properties and biosensor calibration parameters with chlorides: studies with glucose oxidase.
We studied the modulation of calibration parameters of biosensors, in which glucose oxidase was used for bio-recognition, in the presence of different chlorides by fol...
BOD biosensor based on the yeast Debaryomyces hansenii immobilized in poly(vinyl alcohol) modified by N-vinylpyrrolidone.
An amperometric biosensor for assessing the biochemical oxygen demand (BOD) was formed by immobilizing Debaryomyces hansenii VKM Y-2482 yeast cells in poly(vinyl alcoh...
A graphene oxide-based fluorescent biosensor for the analysis of peptide-receptor interactions and imaging in somatostatin receptor subtype 2 overexpressed tumor cells.
Analysis of peptide-receptor interactions provides insights for understanding functions of proteins in cells. In this work, we report the development of a fluorescent ...
Stepwise chemical reaction strategy for highly sensitive electrochemiluminescent detection of dopamine.
A stepwise chemical reaction strategy based on the specific recognition of boronic acid to diol, and N-hydroxysuccinimide (NHS) ester to amine group, was designed to c...
Quantitative ratiometric imaging of FRET-biosensors in living cells.
Biosensors based on FRET have been useful in deciphering the dynamics of protein activation events in living cells at subcellular resolutions and in time scales of sec...
Enhanced interpretation of adsorption data generated by liquid chromatography and by modern biosensors.
In this study we demonstrate the importance of proper data processing in adsorption isotherm estimations. This was done by investigating and reprocessing data from fiv...
Near-infrared fluorescence glucose sensing based on glucose/galactose-binding protein coupled to 651-Blue Oxazine.
Near-infrared (NIR) fluorescent dyes that are environmentally sensitive or solvatochromic are useful tools for protein labelling in in vivo biosensor applications such...
Real time analysis of binding between Rituximab (anti-CD20 antibody) and B lymphoma cells.
CD20, expressed on greater than 90% of B-lymphocytic lymphomas, is an attractive target for antibody therapy. Rituximab is a chimeric murine/human-engineered monoclona...