Weak protein-bicelle binding quantification via surface-based DNA nanolevers.
UNLABELLED: To investigate how human dystrophin associates with biomimetic phospholipid bicelles, we applied switchSENSE®, a fluorescence-based biosensing technology t...
Synthetic promoter design in plants: integration of computational and experimental approaches.
Understanding how to engineer transcriptional regulation in plants is key to advancing both fundamental knowledge and practical applications in plant biology. Native g...
Development of a transcription factor-based biosensor strain for reporting α-terpineol production
Terpenes constitute a vast and industrially important class of natural products. Yet, microbial production of many high-value terpenoids remains limited by the difficu...
Identification of ZFTA as a Novel KLHL20 Substrate and Mechanistic Insights Into Fuzzy Binding of Disordered Peptides via Biosensor Analysis and Computational Modelling.
Interactions between peptides based on a region in the zinc finger translocation associated (ZFTA) protein and the Kelch domain of Kelch-like protein 20 (KLHL20Kelch) ...
Enhanced urine glucose sensing using two-dimensional TMDCs-based SPR biosensor.
Surface plasmon resonance (SPR) sensing technology has been extensively applied in biomedical applications, but traditional SPR sensors often suffer from limited sensi...
Disposable non-enzymatic impedimetric biosensor using Mn-doped ZnS-chitosan nanocomposite for tetracycline detection.
Monitoring antibiotic residues in aquaculture water is critical for food safety, environmental protection, and antimicrobial stewardship. Here, we present a proof-of-c...
Evanescent Wave-Based Photonic Biosensors for the Design and Evaluation of Advanced Cancer Immunotherapies.
Personalized immunotherapies hold great promise for correcting cellular dysfunction, inhibiting tumor growth, and even achieving durable cancer eradication. However, c...
Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregates.
Tau aggregates contribute to multiple neurodegenerative diseases including frontotemporal dementia and Alzheimer's disease (AD). In models of tauopathy and in patient ...
A Symmetric U-Shaped Gate Tunnel FET-ISFET Hybrid Label-Free Biosensor for Highly Sensitive DNA Detection.
Ion-Sensitive Field-Effect Transistors (ISFETs) have been extensively used to detect various biomolecules, as the intrinsic charge of these molecules can change the tr...
Feasibility and Form Factor Validation of Reflective Shoulder-Mounted Pulse Oximeter in Patients with Suspected Sleep Apnea.
The shoulder may be an effective central site for continuous oxygen saturation (SpO2) monitoring but studies of shoulder-mounted pulse oximetry technology are limited....
Use of the Feature Scaling and Machine Learning Techniques on Optical Fiber Biosensors for the Detection of Neuroprotector IL-10 in Serum of a Murine Model with Cerebral Ischemia.
Typically, response analysis of optical fiber biosensors focuses on changes in amplitude and wavelength shifts in the biosensor spectrum; therefore, not all of the spe...
Machine-Learning-Assisted Buried-Window FET Sensors for High-Reliability and High-Sensitivity Applications.
This paper presents a novel Double Buried-Window Junctionless Field-Effect Transistor (DBW-FET) designed for high-sensitivity, label-free biosensing applications. The ...
Psoralen and Isopsoralen from
Background: Non-small cell lung carcinoma (NSCLC) is the most prevalent form of lung cancer, and its progression is closely associated with constitutive activation of ...
Single-Die-Level MEMS Post-Processing for Prototyping CMOS-Based Neural Probes Combined with Optical Fibers for Optogenetic Neuromodulation.
The integration of complementary metal-oxide-semiconductor (CMOS) and micro-electromechanical systems (MEMSs) technologies for miniaturized biosensor fabrication enabl...
A Portable Extended-Gate FET Integrated Sensing System with Low-Noise Current Readout for On-Site Detection of
Field-effect transistor (FET) biosensors enable label-free and real-time electrical transduction; however, their practical deployment is often constrained by the need ...
Nanomaterials-Based Electrochemical Aptasensors for Rapid Detection of Pathogens and By-Products.
The rapid and accurate detection of pathogenic bacteria and viruses is essential for controlling infectious disease outbreaks and ensuring food safety. Conventional de...
Identification of Neferine as a DOR Agonist Activating G
Benzylisoquinoline alkaloids (BIAs) exhibit diverse biological activities, such as neuroprotective effects. The delta-opioid receptor (DOR) has emerged as a promising ...
New SPRi Biosensors for Simultaneous Detection of Tau Protein Isoforms-The Importance of the Ptau181/Total Tau Ratio in Alzheimer's Disease.
Background: Tau protein is a nonspecific marker of neurodegeneration, and its phosphorylated form, ptau-181, is specifically associated with Alzheimer's disease (AD). ...
Toward Smart Salivary Diagnostics: A Comprehensive Review of Heavy Metal Biomarkers and Digital Risk Modeling.
Background: Saliva has been identified as a valuable diagnostic biofluid due to its non-invasive collection and its capacity to reflect oral and systemic biological pr...
Enhanced design of a photonic crystal biosensor for early cervical cancer detection using refractive index variation and neural network classification.
This study introduces a new optical sensor designed to help detect cervical cancer early, using light and special materials called photonic crystals. The sensor has be...