Regulation of Metabolic Pathways by MarR Family Transcription Factors.
Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways. Such regulatory circuits ensure that anabolic pathways remain repressed unless fin...
The power of bioluminescence imaging in understanding host-pathogen interactions.
Infectious diseases are one of the leading causes of death worldwide. Modelling and understanding human infection is imperative to developing treatments to reduce the ...
Electrochemical detection of cardiac biomarker myoglobin using polyphenol as imprinted polymer receptor.
An electrochemical biosensor was developed by merging the features of Molecular Imprinting technique and Screen-Printed Electrode (SPE) for the simple and fast screeni...
Direct Electron Transfer-type Bioelectrocatalysis of Peroxidase at Mesoporous Carbon Electrodes and Its Application for Glucose Determination Based on Bienzyme System.
Non-catalytic direct electron transfer (DET) signal of Compound I of horseradish peroxidase (POD) was first detected at 0.7 V on POD/carbon nanotube mixture-modified e...
Shape anisotropy enhanced optomagnetic measurement for prostate-specific antigen detection via magnetic chain formation.
We demonstrate a homogeneous biosensor for the detection of multivalent targets by combination of magnetic nanoparticle (MNP) chains and a low-cost 405nm laser-based o...
Current advances and future visions on bioelectronic immunosensing for prostate-specific antigen.
Early cancer diagnosis remains the holy-grail in the battle against cancers progression. Tainted with debates and medical challenges, current therapeutic approaches fo...
Two-dimensional ytterbium oxide nanodisks based biosensor for selective detection of urea.
Herein, we demonstrate synthesis and application of two-dimensional (2D) rectangular ytterbium oxide (Yb2O3) nanodisks via a facile hydrothermal method. The structural...
Quorum sensing molecules production by nosocomial and soil isolates Acinetobacter baumannii.
Acinetobacter species remain alive in hospitals on various surfaces, both dry and moist, forming an important source of hospital infections. These bacteria are natural...
Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.
In pancreatic β cells, muscarinic cholinergic receptor M3 (M3R) stimulates glucose-induced secretion of insulin. Regulator of G-protein signaling (RGS) proteins are cr...
A polyamidoamine dendrimer-streptavidin supramolecular architecture for biosensor development.
A novel polyamidoamine dendrimer-streptavidin supramolecular architecture suitable as a versatile platform for biosensor development is reported. The dendrimer was ele...
Fluorescence turn-off-on probe based on polypyrrole/graphene quantum composites for selective and sensitive detection of paracetamol and ascorbic acid.
In this work, we presented a novel biosensor for rapid detection of paracetamol and ascorbic acid. The novel biosensor was based on the fluorescent "turn off-on" of po...
Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, fle...
Developing a Genetically Encoded, Cross-Species Biosensor for Detecting Ammonium and Regulating Biosynthesis of Cyanophycin.
Responding to nitrogen status is essential for all living organisms. Bacteria have evolved various complex and exquisite regulatory systems to control nitrogen metabol...
Pyrrolo-dC modified duplex DNA as a novel probe for the sensitive assay of base excision repair enzyme activity.
We develop a novel approach to determine formamidopyrimidine DNA glycosylase (Fpg) activity by taking advantage of the unique fluorescence property of pyrrolo-dC (PdC)...
Zinc(II) phthalocyanine fused in peripheral positions octa-substituted with alkyl linked carbazole: Synthesis, electropolymerization and its electro-optic and biosensor applications.
Zinc(II) phthalocyanine fused in peripheral positions octa-substituted with alkyl linked carbazole has been prepared by cyclomerization reaction of 4,5-bis(6-carbazole...
Hybrid PbS Quantum Dot/Nanoporous NiO Film Nanostructure: Preparation, Characterization, and Application for a Self-Powered Cathodic Photoelectrochemical Biosensor.
This work reports the first preparation and characterization of a hybrid PbS quantum dot (QD)/nanoporous NiO film nanostructure as well as its application for novel se...
Selective and High Dynamic Range Assay Format for Multiplex Detection of Pathogenic Pseudomonas aeruginosa, Salmonella typhimurium, and Legionella pneumophila RNAs Using Surface Plasmon Resonance Imaging.
Due to its well-characterized and highly conserved structure, as well as its relative abundance in metabolically active cells, bacterial 16S rRNA sequence plays an imp...
An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics.
A primary limitation preventing practical implementation of photonic biosensors within point-of-care platforms is their integration with fluidic automation subsystems....
Early Diagnosis of Breast Cancer.
Early-stage cancer detection could reduce breast cancer death rates significantly in the long-term. The most critical point for best prognosis is to identify early-sta...
Embroidered electrochemical sensors on gauze for rapid quantification of wound biomarkers.
Electrochemical sensors are an attractive platform for analytical measurements due to their high sensitivity, portability and fast response time. These attributes also...