Functional DNA nanostructures for theranostic applications.
There has been tremendous interest in constructing nanostructures by exploiting the unparalleled ability of DNA molecules in self-assembly. We have seen the appearance...
Electrochemical biosensors featuring oriented antibody immobilization via electrografted and self-assembled hydrazide chemistry.
Appropriate site-directed chemistry is essential to maximize the performance of immunosensors. We present two new functionalization strategies that preserve proper fol...
Multiplex electrical detection of avian influenza and human immunodeficiency virus with an underlap-embedded silicon nanowire field-effect transistor.
The label-free electrical detection of the binding of antibodies and antigens of avian influenza (AI) and human immunodeficiency (HIV) viruses is demonstrated through ...
Voltammetric discrimination of mandelic acid enantiomers.
We report a novel electrochemical biosensor for direct discrimination of D- and L-mandelic acid (D- and L-MA) in aqueous medium. The glassy carbon electrode (GCE) surf...
Complex thiolated mannose/quinone film modified on EQCM/Au electrode for recognizing specific carbohydrate-proteins.
A complex thiolated mannose (TM)/quinone functionalised polythiophene (QFPT) thin film was modified on EQCM/Au electrode for recognition of specific carbohydrate-prote...
Effects of nanoparticle size and cell type on high sensitivity cell detection using a localized surface plasmon resonance biosensor.
A localized surface plasmon resonance (LSPR) effect was used to distinguish cell concentration on ordered arrays of Au nanoparticles (NPs) on glass substrates. Human-d...
Enhancing the detection limit of nanoscale biosensors via topographically selective functionalization.
Nanoscale biosensors have remarkable theoretical sensitivities but often suffer from suboptimal limits of detection in practice. This is in part because the sensing ar...
Noninvasive evaluation of heavy metal uptake and storage in micoralgae using a fluorescence resonance energy transfer-based heavy metal biosensor.
We have developed a fluorescence resonance energy transfer (FRET)-based heavy metal biosensor for the quantification of bioavailable free heavy metals in the cytoplasm...
A novel amperometric alcohol biosensor developed in a 3rd generation bioelectrode platform using peroxidase coupled ferrocene activated alcohol oxidase as biorecognition system.
Alcohol oxidase (AOx) with a two-fold increase in efficiency (Kcat/Km) was achieved by physical entrapment of the activator ferrocene in the protein matrix through a s...
An amperometric β-glucan biosensor based on the immobilization of bi-enzyme on Prussian blue-chitosan and gold nanoparticles-chitosan nanocomposite films.
A novel β-glucan biosensor was fabricated by immobilizing β-glucanase (β-G) with glucose oxidase (GOD) on nano-Prussian blue-chitosan (PB-CS) and gold nanoparticles-ch...
Approaches to label-free flexible DNA biosensors using low-temperature solution-processed InZnO thin-film transistors.
Low-temperature solution-processed In-Zn-O (IZO) thin-film transistors (TFTs) exhibiting a favorable microenvironment for electron transfer by adsorbed artificial deox...
Colorimetric detection of DNA hybridization based on a dual platform of gold nanoparticles and graphene oxide.
The unique property of gold nanoparticles (Au NP) to induce colour change and the versatility of graphene oxides (GO) in surface modification makes them ideal in the a...
A high sensitivity MEA probe for measuring real time rat brain glucose flux.
The mammalian central nervous system (CNS) relies on a constant supply of external glucose for its undisturbed operation. This article presents an implantable Multi-El...
Inducing electrocatalytic functionality in ZnO thin film by N doping to realize a third generation uric acid biosensor.
A third generation uric acid biosensor has been developed by exploiting the electrocatalytic functionality of nitrogen (N) doped zinc oxide (ZnO:N) thin film matrix de...
Death domain complex of the TNFR-1, TRADD, and RIP1 proteins for death-inducing signaling.
Apoptosis can be induced by an extrinsic pathway involving the ligand-mediated activation of death receptors such as tumor necrosis factor receptor-1 (TNFR-1). TNFR-1-...
Electrochemical biosensor based on base-stacking-dependent DNA hybridization assay for protein detection.
An antibody-based electrochemical biosensing platform has been developed and used for the detection of protein. In the presence of the target, an antibody pair binds t...
Biosensor for organoarsenical herbicides and growth promoters.
The toxic metalloid arsenic is widely distributed in food, water, and soil. While inorganic arsenic enters the environment primarily from geochemical sources, methylar...
The β-cell/EC axis: how do islet cells talk to each other?
Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is to accurately sense glucose levels in the blood and consequently rel...
Fluorescent biosensors for high throughput screening of protein kinase inhibitors.
High throughput screening assays aim to identify small molecules that interfere with protein function, activity, or conformation, which can serve as effective tools fo...
Coiled-coil peptide based sensor for ultra-sensitive thrombin detection.
Comb structured gold microelectrode array (CSGMA) functionalized with self-assembled monolayer of thiol terminated coiled-coil peptide (CCP) linked together by the thr...