On-site quantitative Hg
Mercury is a bio-accumulative and toxic pollutant causing severe damages to human health and environment. Since Hg2+ is the most stable form of mercury, selective and ...
Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum.
The calcium-regulated phosphodiesterase 1 (PDE1) family is highly expressed in the brain, but its functional role in neurones is poorly understood. Using the selective...
Isolation of novel quorum-sensing active bacteria from microbial mats in Shark Bay Australia.
Quorum sensing is a potent system of genetic control allowing phenotypes to be coordinated across localized communities. In this study, quorum sensing systems in Shark...
Cellular sensing by phase separation: Using the process, not just the products.
Phase separation creates two distinct liquid phases from a single mixed liquid phase, like oil droplets separating from water. Considerable attention has focused on ho...
Probe-specific loop-mediated isothermal amplification magnetogenosensor assay for rapid and specific detection of pathogenic Leptospira.
This study highlighted the performance of the developed integrated loop-mediated isothermal amplification (LAMP) coupled with a colorimetric DNA-based magnetogenosenso...
Hairpin probes based click polymerization for label-free electrochemical detection of human T-lymphotropic virus types II.
A novel, simple, and label-free amplification electrochemical impedance method for quantitative detection of Human T-lymphotropic virus types II(HTLV-II) via click che...
Sensitive and specific detection of proteins based on target-responsive DNA polymerase activity.
We herein describe a novel method for the detection of target protein based on the target-responsive DNA polymerase activity. In the sensor, two different types of DNA...
A SERS nano-tag-based magnetic-separation strategy for highly sensitive immunoassay in unprocessed whole blood.
Assay technologies capable of detecting biomarker concentrations in unprocessed whole blood samples are fundamental for applications in medical diagnostics. SERS nano-...
Facile fabrication of visible light photoelectrochemical immunosensor for SCCA detection based on BiOBr/Bi
A novel visible light photoelectrochemical immunosensor based on BiOBr/Bi2S3 heterostructures was fabricated to detect squamous cell carcinoma antigen (SCCA). Bi2S3 na...
A portable and quantitative biosensor for cadmium detection using glucometer as the point-of-use device.
As an ubiquitous heavy metal pollutant, cadmium ion (Cd2+) is detrimental to food and human health even at low concentrations. Conventional methods require costly inst...
Acrylic-based genosensor utilizing metal salphen labeling approach for reflectometric dengue virus detection.
An optical genosensor based on Schiff base complex (Zn2+ salphen) DNA label and acrylic microspheres (AMs) as polymer support of the capturing DNA probe (cpDNA) was de...
Cascade signal amplified assay of nucleic acids based on entropy-driven amplification strategy and Mg
Nucleic acids-based biosensors are extremely important in modern life sciences and have been widely used for the detection of many biomarkers of disease and extensivel...
Detection of KRAS G12D point mutation level by anchor-like DNA electrochemical biosensor.
KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast canc...
Nanoplasmonic swarm biosensing using single nanoparticle colorimetry.
We demonstrate a swarm biosensing platform that detects analyte based on the change in plasmonic signal from thousands of single nanoparticles sensors, leading to incr...
Single-particle correlation study: chemical interface damping induced by biotinylated proteins with sulfur in plasmonic gold nanorods.
Plasmonic gold nanoparticles can be an efficient source of hot electrons that can transfer to adsorbed molecules for photochemistry, followed by broadening of the homo...
Fluorescence, turn-on detection of melamine based on its dual functions as fluorescence enhancer of DNA-AgNCs and Hg(II)-scavenger.
A new method has been developed for the simple, fluorescence, turn-on detection of melamine, which utilizes DNA-templated silver nanoclusters (DNA-AgNCs) as a key comp...
An Observational Study With the Janssen Autism Knowledge Engine (JAKE
Objective: The Janssen Autism Knowledge Engine (JAKE®) is a clinical research outcomes assessment system developed to more sensitively measure treatment outcomes and i...
Cell-free expression, purification and characterization of Drosophila melanogaster odorant receptor OR42a and its co-receptor.
Olfactory receptors (OR), a group of classic membrane proteins, plays a vital role in insect reproduction and acclimatization. Deciphering the molecular mechanism of i...
Volume discrimination of nanoparticles via electrical trapping using nanopores.
Electrophoretic capture of an oversized object on a solid-state nanopore is a useful approach for single-particle analyses via post electrical and optical measurements...
Identification of
Leishmaniasis is a neglected disease that is caused by different species of the protozoan parasite Leishmania, and it currently affects 12 million people worldwide. Th...