In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects.
本文在体外模型中筛选益生菌、益生元和合生元的抗炎与抗增殖作用。为模拟炎症性肠病对革兰阴性菌的反应,先用IFNγ上调HT-29细胞TLR4表达,再以LPS刺激,检测分泌型IL-8和激活型NF-κB。结果显示,11株乳酸菌具有抗炎活性,其中5株显著抑制IL-8分泌和NF-κB激活;益生元低聚葡萄糖单独无抗炎作用。随后用NF-κB启动子控...