New insights into mechanisms behind miscarriage.

Sporadic miscarriage is the most common complication of early pregnancy. Two or three consecutive pregnancy losses is a less common phenomenon, and this is considered ...

Simultaneous quantification of the fluorescent responses of an ensemble of bacterial sensors.

Bacterial bioreporters are genetically engineered microbial strains capable of detecting specific chemicals, groups of chemicals or global biological effects such as t...

Oriented antibody immobilization by site-specific UV photocrosslinking of biotin at the conserved nucleotide binding site for enhanced antigen detection.

The nucleotide binding site (NBS) is an under-utilized, highly conserved binding site found within the variable region of nearly all antibody Fab arms. Here, we descri...

Pt-Pd bimetallic nanoparticles dispersed in an ionic liquid and peroxidase immobilized on nanoclay applied in the development of a biosensor.

Pt-Pd bimetallic alloy nanoparticles (NPs) dispersed in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate (Pt-Pd-BMI·PF6) were employed together with a ...

The differential detection of methicillin-resistant, methicillin-susceptible and borderline oxacillin-resistant Staphylococcus aureus by surface plasmon resonance.

Two hundred fifty Staphylococcus aureus clinical isolates were studied to determine their susceptibilities to β-lactam antibiotics. Among these isolates, 16 were methi...

Dual-functionalized porous Si/hydrogel hybrid for label-free biosensing of organophosphorus compounds.

A multifunctional porous Si (PSi) nanostructure is designed to combine a responsive PSi/hydrogel hybrid interfaced with a biorecognition element to selectively recogni...

Electrical field manipulation of cancer cell behavior monitored by whole cell biosensing device.

All living cells possess electrical characteristics and are thus responsive to, and even generate electric fields and currents. It has been shown that the electrical p...

Functionalized 129Xe as a potential biosensor for membrane fluidity.

Using spin hyperpolarized xenon ((129)Xe) we investigate the impact of the local molecular environment on reversible host-guest interactions. We label Xe guest atoms t...

Computational design of peptide ligands for ochratoxin A.

In this paper, we describe a peptide library designed by computational modelling and the selection of two peptide sequences showing affinity towards the mycotoxin, och...

Synthesis of mesoporous multiwall ZnO nanotubes by replicating silk and application for enzymatic biosensor.

A facial biotemplate-directed synthetic route for fabricating mesoporous multiwall ZnO nanotubes (ZnO-MMNTs) was proposed. Owing to the mesoporous multiwall based matr...

Knowledge-based design of a biosensor to quantify localized ERK activation in living cells.

Investigation of protein activation in living cells is fundamental to understanding how proteins are influenced by the full complement of upstream regulators they expe...

A two-channel ratiometric electrochemical biosensor for in vivo monitoring of copper ions in a rat brain using gold truncated octahedral microcages.

Embryo implantation: biology, evaluation, and enhancement.

PURPOSE OF REVIEW: Implantation is an essential step in the development of a pregnancy, but often fails in humans. In assisted reproductive technologies, implantation ...

A quantitative ratiometric sensor for time-resolved analysis of auxin dynamics.

Time-resolved quantitative analysis of auxin-mediated processes in plant cells is as of yet limited. By applying a synergistic mammalian and plant synthetic biology ap...

Fullerene-nitrogen doped carbon nanotubes for the direct electrochemistry of hemoglobin and its application in biosensing.

The direct electrochemistry of hemoglobin (Hb) immobilized by a fullerene-nitrogen doped carbon nanotubes and chitosan (C60-NCNTs/CHIT) composite matrix is demonstrate...

Photolithographic strategy for patterning preformed, chemically modified, porous silicon photonic crystal using click chemistry.

Porous silicon (PSi) is an ideal platform for label-free biosensing, and the development of porous silicon patterning will open a pathway to the development of highly ...

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise.

Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress. Acco...

An electrochemical one-step system for assaying methyltransferase activity based on transport of a quantum dot signaling tracer.

A one-step, electrochemical method for assaying methyltransferase (MTase) activity, based on the convective transport of a quantum dot (QD) signaling tracer, has been ...

A novel analytical probe binding to a potential carcinogenic factor of N-glycolylneuraminic acid by SELEX.

N-glycolylneuraminic acid (Neu5Gc) is an abundant sialic acid in many mammals and is present in the glycoconjugates of most deuterostome animals. Neu5Gc also occurs in...

Single embryo-coupled gate field effect transistor for elective single embryo transfer.

In this study, we have proposed and demonstrated experimentally a novel monitoring device of single mouse embryo activity after in vitro fertilization (IVF) using a se...