Circulating cycloxygenase-2 in patients with tobacco-related intraoral squamous cell carcinoma and evaluation of its peptide inhibitors as potential antitumor agent.
本研究旨在定量检测烟草相关口腔癌患者循环中的COX-2水平,并评估COX-2肽抑制剂对KB口腔癌细胞的体外抗肿瘤活性。作者采用新型生物传感器表面等离子共振(SPR)技术,检测76例口腔癌患者和43例正常对照的血清COX-2水平;同时用碘化丙啶(PI)标记流式细胞术、Alamar Blue、MTS和Annexin V结合实验评价5种C...