Development of Novel Bioluminescent Sensor to Detect and Discriminate between Vitamin D Receptor Agonists and Antagonists in Living Cells.

活性维生素D通过维生素D受体（VDR）调控钙磷稳态、细胞分化和免疫相关基因表达。许多维生素D类似物已用于I型佝偻病、骨质疏松、肾性骨营养不良、银屑病、白血病和乳腺癌等治疗。作者构建了含拆分荧光素酶和VDR配体结合域（LBD）的两种融合蛋白：LucN-LBD-LucC和LucC-LBD-LucN。其中LucC-LBD-LucN（荧光素...